What hypoglycemic drugs can be used in patient with chronic renal disease (CKD)?
The table shows a summary correlating the therapeutic class and the dose adjustment based on creatinine clearance. Class and Medication [...]
Metformin-insulin versus metformin-sulfonylurea combination therapies in type 2 diabetes
High proportion of patients who received metformin-sulfonylurea achieved target HbA1c level and had less composite cardiovascular outcomes compared to those [...]
What is the efficacy of once-weekly semaglutide vs empagliflozin added to metformin in type 2 diabetes?
Using individual patient data (IPD) and meta-regression methodology, researchers sought to indirectly compare the effectiveness of once-weekly (OW) semaglutide 1 mg vs once-daily (OD) empagliflozin 25 mg in patients with type 2 diabetes (T2D) inadequately controlled on metformin monotherapy. IPD for patients with T2D receiving metformin monotherapy and randomized to OW semaglutide 1 mg (SUSTAIN 2, 3, 8 trials), or to OD empagliflozin 25 mg (PIONEER 2 trial) have been involved. Findings revealed that baseline features were comparable between OW semaglutide (n = 995) and empagliflozin (n = 410). According to this indirect comparison, OW semaglutide 1 mg gives superior declines in HbA1c and body weight vs OD empagliflozin 25 mg in patients with T2D when added to metformin monotherapy. Conclusions This indirect comparison suggests that OW semaglutide 1 mg provides superior reductions in HbA1c and body weight vs OD empagliflozin [...]
What Is The Difference Between Sulfonylureas And Meglitinides?
Sulfonylureas and Meglitinides are oral hypoglycemic drugs directly stimulate release of insulin from pancreatic beta cells. Meglitinides act on the same [...]
What drugs are SGLT2 inhibitors?
SGLT2 inhibitors, also called gliflozins, are a class of medications that inhibit reabsorption of glucose in the kidney and therefore [...]
What Are The Common Side Effects Of SGLT2 Inhibitors?
According to the drugs’ labels, the most common SGLT2 side effects are vaginal yeast infections, yeast infections of the penis, [...]
What Are the Pros and Cons of SGLT2 Inhibitors for Type 2 Diabetes?
SGLT2 inhibitors may help people with type 2 diabetes who already have heart disease, according to an empagliflozin study published in [...]
What Is The Difference Between DPP-4 Inhibitors And Sulfonylureas?
When compared in a cursory manner, DPP-4 inhibitors and sulfonylureas seem to be totally different classes of drugs. However, we [...]
Is Peripheral Neuropathy a Side Effect of Metformin?
Chronic Metformin use results in vitamin B12 deficiency in many diabetic patients. A potential consequence of B12 deficiency is that it could [...]
Why Metformin Makes Exercise More Difficult?
Because, Metformin makes your body think it's working out and additional exercise is difficult. A study just published in Aging Cell reports [...]
