When lovastatin (Mevacor) was approved by the FDA  in 1987 there was no hint that it could raise blood sugar. Ditto for many of the popular statins that followed, such as atorvastatin (Lipitor), Rosuvastatin (Crestor), pravastatin (Pravachol) and simvastatin (Zocor). The drug company-sponsored-clinical trials did not detect a metabolic problem. It took the FDA roughly 15 more years to send out a warning that: “Increases in blood sugar levels have been reported with statin use” (FDA Drug Safety Communication, Feb. 28, 2012).  Now, seven years later comes confirmation that statins cause diabetes (British Journal of Clinical Pharmacology, March 5, 2019).

When the cholesterol-lowering drug rosuvastatin (Crestor) was associated with type 2 diabetes in the JUPITER trial, many cardiologists were skeptical (New England Journal of Medicine, Nov. 8, 2008).  Even the researchers who conducted the trial seemed to downplay the idea that statins cause diabetes. There was no mention in the all-important conclusions that there was a connection between rosuvastatin and diabetes.

Recent findings, which appear in the journal Diabetes Metabolism Research and Reviews, revealed that people who took statins were more than twice as likely to receive a diabetes diagnosis than those who did not take the medication. In this new study, US researchers at the Ohio State University collected data from more than 4,600 men and women who did not have diabetes and were deemed suitable candidates for statins  Additionally, people who took statins for longer than 2 years were more than three times as likely to develop diabetes.

Individuals who take cholesterol-lowering statins may be at higher risk for developing high blood sugar levels, insulin resistance, and eventually type 2 diabetes, according to an analysis on more than 9500 adults published in the (British Journal of Clinical Pharmacology, March 5, 2019). Compared with participants who never used statins, those who used statins tended to have higher concentrations of serum fasting insulin and insulin resistance. Participants who ever used statins had a 38 percent higher risk of developing type 2 diabetes during the study. Even in 2014 we knew that statins can lead to weight gain, raised blood sugar levels.

According to results from a study published on 15 May 2020 in the Journal of the Endocrine Society, the use of statin therapy is also associated with elevated levels of insulin resistance in older patients.

In october 2021, a retrospective matched-cohort study published in the journal JAMA Internal Medicine  which included 12 years of data (2003 – 2015) from 83 022 statin users and nonusers found that statin use was associated with diabetes progression, including greater likelihood of insulin treatment initiation, significant hyperglycemia, acute glycemic complications, and an increased number of prescriptions for glucose-lowering medication classes. 

Shockingly, the Huffington post in 2011 reports that a recent scientific review of 14 studies shows that statins are virtually useless for primary prevention.

It is a pity that mainstream doctors ignore the fact that more 75% of people who suffer heart attacks have normal or low levels of cholesterol. And they downplay the side effects.

One of the most common complaints of people taking statins is muscle pain. One may feel this pain as a soreness, tiredness or weakness in your muscles. statins can cause life-threatening muscle damage called rhabdomyolysis, which can cause severe muscle pain, liver damage, kidney failure and death.

The FDA warns on statin labels that some people have developed memory loss or cognitive impairment while taking statins.

In contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis, statins may be causative in coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and ‘heme A’, and thereby ATP generation. Statins inhibit the synthesis of vitamin K2, the cofactor for matrix Gla-protein activation, which in turn protects arteries from calcification. Statins inhibit the biosynthesis of selenium containing proteins, one of which is glutathione peroxidase serving to suppress peroxidative stress. An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure, reminiscent of the dilated cardiomyopathies seen with selenium deficiency. Thus, the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs.

Now, a new study from 165,411 patients on statins without disease or had suffered a stroke shows that statins don’t even do the one thing they are supposed to do: lower cholesterol. Researchers found that after two years on statins, 51% of the patients failed to reach the standard goal of reducing LDL (bad) cholesterol by 40% or more.

A recent massive study review coordinated by 16 medical scholars and practicing MDs throughout England, Ireland, Italy, Japan, Sweden, and the USA has confirmed the falsity of the lipid theory of heart disease that blames cholesterol, and the disinformation and dangers of cholesterol-lowering statin drugs.

  • Statins interfere with the production of coenzyme Q10, which supports the body’s immune and nervous systems, boosts heart and other muscle health, maintains normal blood pressure, and much more. Of all the organs, the heart requires the most energy and CoQ10 to function properly. So why take a medication for heart health that depletes a vital nutrient shown to support the heart—as well as every cell in your body? Low levels of CoQ10 have also been linked to depression and dementia, as well as muscle weakness, fatigue, pain, and nerve damage—all of which are also known side effects of statins. 
  • Statins weaken the immune system, make it difficult to fight off bacterial infections, and increase the production of cytokines, which trigger and sustain inflammation.
  • Statins make some patients unable to concentrate or remember words, and are linked to muscle and neurological problems, including Lou Gehrig’s Disease (Amyotrophic Lateral Sclerosis).
  • Statins inhibit the beneficial effects of omega-3 fatty acids by promoting the metabolism of omega-6 fatty acids, which increases insulin resistance and the risk of developing diabetes.
  • There is evidence that statin use blocks the benefits of exercise. Exercise increases the activity and numbers of mitochondria, cells’ “power plants” that process sugars and fat. The study found that with statin use, mitochondrial activity actually decreases with exercise.
  • Statins work by reducing the body’s ability to produce cholesterol, which is essential to brain health—the brain is 2% of the body’s weight, but contains 25% of the entire body’s cholesterol.
  • Statin users have a higher incidence of nerve degeneration and painmemory lossconfusiondepression, and a higher risk of ALS and Parkinson’s. Statins also decrease carotenoid levels. Carotenoids, which are found in fresh fruits and vegetables and act as antioxidants, have a number of benefits, including protecting against cell damage, aging, and chronic diseases.
  • People taking statins were 14 times more likely to develop peripheral neuropathy than people who were not taking statins, according to the Danish study.
  • Statin drugs may also be driving Americans to overeat: a twelve-year study published in JAMA Internal Medicine found that statin users increased their calorie intake by 9%, and fat consumption by 14.4%, over the study period, whereas those who didn’t take statins didn’t significantly change in either measure.
  • An animal study linked statin use to muscle damage. Animals that exercised on statins had 226% more muscle damage than those not given statins.
  • Statins affect the quality of sleep.
  • Statins increase the risk of prostate and breast cancer.
  • Statins are known to cause liver damage by increasing the liver’s production of digestive enzymes.
  • Statins also speed aging and lower sex drive.
  • Statins have been linked to aggressive and violent behavior in women.

Studies reported by TheNNT.com on statins given over a five-year period to people with no known heart disease is a good example of why you need to be aware of the Number Needed to Treat (NNT) and Number Needed to Harm (NNH) for any drug. Over 5 years, the NNT for statins showed that no patients had their lives saved. In addition, only one patient in 104 had a heart attack prevented, and only 1 in 154 had a stroke prevented. However, these same studies showed that 1 in 100 were harmed because they developed diabetes as a direct result of stains, and 1 in 10 developed muscle damage as a direct result!

Conclusion: Statin Drugs seems to be Useless and Dangerous by being one of the greatest failures in modern medicine.

Cholesterol is the source material for all sex hormones including estrogens, progesterone, testosterone, and adrenal hormones such as DHEA, and hydrocortisone. Our brains depend upon the hormones made from cholesterol as much as the rest of our body does. Progesterone and pregnenolone protect the nervous tissue throughout our body. A common explanation for the depletion of DHEA and other hormones (e.g., progesterone, testosterone) due to chronic stress is the phenomenon known as “pregnenolone steal.” Elevated cholesterol may simply be a signal the body is working hard to replenish these hormones in the event hormone levels are low. Cholesterol levels may also increase when thyroid hormone production is inadequate. Correcting sex hormone deficiencies, chronic stress and hypothyroidism may bring cholesterol levels down.

Most people know that statins can cause muscle pain and weakness. Not that many realize that there is now enough data to suggest statins cause diabetes.


Dietary cholesterol had been labeled “dangerous” by the FDA for decades until it fully reversed that stance in 2018. In fact, the 2015–2020 Dietary Guidelines for Americans removed the recommendations of setting a limit to the maximum intake of 300 mg/day cholesterol.