The TyG index is a good discriminant of Metabolic Syndrome and is a surrogate marker of insulin resistance.

The TyG index predicts future major adverse cardiovascular events (MACE) in patients with diabetes and acute coronary syndrome (ACS) independently of known cardiovascular risk factors, suggesting that the TyG index may be a useful marker for risk stratification and prognosis in patients with diabetes and ACS.

The triglyceride glucose index (TyG) was found to be an independent marker for predicting subclinical coronary artery disease (CAD) in individuals with no traditional cardiovascular risk factors (CVRFs).

The TyG index is an independent predictor of coronary artery calcification (CAC) progression, especially in adults without heavy baseline CAC.

TyG-index is significantly associated with incident Nonalcoholic fatty liver disease (NAFLD).

TyG index cut-off point of >4.44 was established for IR prediction.

TyG is superior to discriminate diabetes status, showing no inferior ability compared to the HOMA-IR. One important strength of TyG is a lower cost compared to HOMA-IR, as the cost of a fasting insulin level measurement is about six times higher than the cost of a triglyceride test. Therefore, we suggest the use of LAP and TyG as accurate, convenient and cost-effective diagnostic measurements for the early detection of prediabetes/diabetes in the general population.