Regular exercise has a significant benefit on insulin sensitivity, which may persist for 72 hours or longer after the last training bout.

Latest findings suggest that short periods of inactivity (e.g., 72 hours) may not result in a loss of insulin sensitivity, and this may reflect chronic adaptations to the underlying pathophysiology. Therefore, clinicians should reinforce the importance of regular exercise to manage insulin sensitivity as these chronic benefits may ensure that short-term periods of inactivity will not negate the therapeutic effect from generally regular exercise participation.